Sansepolcro, formerly Borgo Santo Sepolcro, is a town and comune founded in the 11th century, located in the Italian Province of Arezzo in the eastern part of the region of Tuscany.

It was also the birthplace of the Italian mathematician Luca Pacioli, and of Matteo Cioni, who translated Piero della Francesca's treatise about perspective in painting (De prospectiva pingendi) into Latin.

During the conflicts between the Guelfs and Ghibellines, the town's factions were headed by prominent local families, including the Pichi, Bercordati, Graziani and Bacci.

[5] Due to its central location on the local trade routes, in the 13th century control of the town was contested and seized by various forces of the region, passing from Uguccione della Faggiola, Lord of Pisa, to Guido Tarlati, Bishop of Arezzo, and his brother, Pier Saccone Tarlati di Pietramala, who ruled it from Città di Castello.

The English writer Aldous Huxley described the Resurrection by Piero della Francesca, which is in the Museo Civico, as "the greatest painting in the world".