Her contributions to protein structural biology[1] includes the use of NMR and X-ray crystallography to pursue structures of proteins on a proteome wide scale.
One of her areas of interest is the tumour suppressor p53 and related proteins.
[3] She has made significant contributions to epigenetic signaling in the context of drug discovery.
[4] Arrowsmith was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2015.
[5] She was also named as one of the Clarivate Highly Cited Researchers in 2023.