Cheryl Blossom was introduced in 1982 in Betty and Veronica #320[1] as a third love interest for Archie Andrews, but she and her twin brother Jason disappeared two years later.

In the 1980s, when a number of alternate universe series were published, Cheryl was a minor recurring character in the short-lived title Archie's Explorers of the Unknown.

The character was reintroduced into the main continuity and Archie Andrews' life during the "Love Showdown" four-part series in 1994.

Archie, infatuated with girls as always, decides to keep Cheryl's return a secret from Betty Cooper and Veronica Lodge.

There are stories where Cheryl is rude and condescending to the Riverdale "townies," and sometimes only appearing as an antagonist to Betty and Veronica.

At one point, in the story "Undercover Blossom", Cheryl decided that she would try to get into Riverdale High under false pretenses.

She chose the alias "Shirley Merriwether"; at first nobody thought anything amiss, until she decided to cause trouble, (i.e., sending fake love letters; and stealing a couple of term papers) and then she'd frame Archie for it, almost turning his friends against him.

They were paired together online, without knowing each other's true identity, fell in love, met in real life, and decided to continue their romantic relationship, though this was largely ignored in later stories.

In a reader-poll event, Archie Comics finally gave Cheryl a new boyfriend, with readers voting on the potential boyfriends featured on the show: blond-haired fitness-guru Austin, dark-complected computer genius Brandon, and shaved-headed gourmet chef George.

Cheryl and Jason lived in the neighboring, upscale community of Pembrooke during her second stay in the comic books, which lasted until the quiet cancellation of her title series and her subsequent move to Paris.

Cheryl now lives in Riverdale, and no longer attends Pembrooke, although in some stories she and her brother return to visit friends there.

Cheryl along with her brother Jason appear in the 2013 adult zombie comics series Afterlife with Archie.

Cheryl and Jason take a trip to Los Perdidos Resort for a spring break, until they both were killed by an alien creature hunter, known as the Predator.

In this issue, Cheryl returns to Riverdale; however, unknown to her family and friends back home, she was being treated for breast cancer.

She was introduced as Riverdale's queen bee who is not interested with making friends with the newly transferred Veronica Lodge.

In the second season, her mother forces her into conversion therapy at an institution called "The Sisters of Quiet Mercy", namely due to her attraction towards other girls, mainly Josie McCoy.

After escaping, Cheryl begins a relationship with Toni Topaz, thus joining the Southside Serpents gang in the season finale.

After being kicked out of the Serpents by Jughead, Cheryl thanks Toni for being the best girlfriend ever with a new gang, called the Pretty Poisons.

After visiting Ms. Burble, the guidance counselor, and expressing all of her feelings including that she has her dead brother's body in her basement and is being haunted by a doll, she is replaced by a coach on the cheerleading squad.