Nancy loves fashion, shopping, and having girls nights with her friends Betty Cooper, Veronica Lodge and Midge Klump.

In her early appearances, this was due to Archie Comics considering interracial dating controversial; a series of one-time African-American girls (Georgette, Liza, Gina, etc.

In one story, Chuck's dad Coach Clayton installs a curfew on the basketball team due to poor play.

As a result, everybody on the team improves except for Chuck who was sneaking out of the house in order to date Nancy, that is until Archie shows her the error of her ways.

In the Afterlife with Archie series, which is not official canon, Nancy dates Chuck, but is revealed to be having a secret romantic relationship with her best friend, Ginger Lopez.