The Chesapeake & Indiana Railroad (reporting mark CKIN) is a Class III short-line railroad operating 33 miles (53 km) of rail line in northwestern Indiana.

The Chesapeake & Indiana is mostly used for transporting grain from rural elevators to the mainline railroad systems.

The C&I and NS will soon build a connection in Thomaston to allow more cars per year and competitive shipping rates between the two Class I's.

Rail tours are also operated on the C&I line by the Hoosier Valley Railroad Museum, starting in North Judson and running to English Lake.

CKIN had been owned by the Town of North Judson and was operated under lease by the Indiana Boxcar Corporation until 2019 and Midwest & Bluegrass Rail afterward.