Marketed over a single generation, the Uplander was offered in short and long wheelbase variations — each with foldable and removable second and third row seating; a V-6 engine and 4-speed automatic transmission.

Heavily based on GM's predecessor minivans, the Uplander was initially marketed with those vehicles, the Venture and Astro.

The final vehicle (a 2009 Canadian-specification short wheelbase Pontiac Montana SV6 in Liquid Silver Metallic[citation needed] with a roof rack) rolled off the Doraville assembly line on September 26, 2008.

[3] According to the Insurance Institute for Highway Safety, the Chevrolet Uplander has an improved crash test rating than its predecessor, the Venture.

The Uplander, Pontiac Montana SV6, Buick Terraza, and Saturn Relay earned the highest rating of "Good" in the IIHS offset frontal crash test but was rated only "Acceptable" and "Poor" in the IIHS side crash test with and without the optional side airbags, respectively.