[4] The community was named for the fact Cheyenne Indians maintained water wells near the original town site.

[7] At the 2020 United States Census, the town had a total area of 684 acres (2.770 km2), all of it land.

[4] A small area about 10 miles southwest of Cheyenne Wells is antipodal, or globally opposite, to Île Saint-Paul, an island in the southern Indian Ocean.

Tumbleweed Midstream owns the Ladder Creek Helium Plant near Cheyenne Wells.

Notable individuals who were born in or have lived in Cheyenne Wells include: