The Drumright Drummers, Enid Harvesters, Fort Smith Twins, Henryetta Hens, Okmulgee Drillers, Pawhuska Huskers and Springfield Merchants teams joined the Chicks in beginning league play on April 21, 1920.
[4][1][5] In their first full season of play, the Chickasha Chicks finished with a 52–72 record, placing seventh in the 1920 Western Association.
[4][1][6] The Chickasha Chicks won the 1921 Western Association Championship, playing under returning manager Drap Hayes.
In the playoff Finals, the Chickasha Chicks defeated the Fort Smith Twins four games to three to win the 1921 championship.
[7][8][1][6] Chickasha left the Western Association to join the newly formed Oklahoma State League in 1922 and won their second straight championship.
[11][12][13] Despite limited success over the remainder of the regular season, the team defeated the Clinton Bulldogs in the playoff finals, four games none, to win the 1922 championship.
[1] The Chicks were succeeded by the 1948 Chickasha Chiefs, who began play as members of the Sooner State League.