It is the burial place of the famous Early Renaissance painter, Sandro Botticelli, as well as Age of Discovery-era explorer Amerigo Vespucci, from whom the name "America" is derived.

Soon after, a new façade (1637) was erected using designs by Matteo Nigetti,[n 2] that conserved the glazed terracotta lunette over the doorway, which while resembling the work of Della Robbia, is now attributed to Benedetto Buglioni.

[n 3] Recent cleaning of the Crucifix in the left transept has led this work to be attributed also to Giotto.

In the early 17th-century, the interior was remodeled in Baroque style, with the apse rebuilt with a pietre dure high altar[n 5] and a sotto in su perspective painting (1770) on the vaulted nave ceiling.

When Amerigo found a bay in the actual Brazil, he named to "San Salvatore di Ognissanti", in Portuguese "San Salvador de Todos os Santos": this is the origin of the name of the city of Salvador and Bahia de Todos os Santos.