It is 5 miles (8.0 km) long and runs east–west, entirely within Klamath County.

OR 422 has an unsigned spur in Chiloquin, which runs 0.19 miles (0.31 km).

[4] OR 422 begins at an intersection with Modoc Point Road approximately one mile south of Klamath Agency and heads east, crossing OR 62 0.16 miles (0.26 km) east of the start of the route.

[5][6] At the intersection of Chocktoot Street and Chiloquin Road in Chiloquin, OR 422S heads southeast along Chocktoot Street and OR 422 turns southwest along Chiloquin Road, ending at an intersection with US 97 approximately 0.60 miles (0.97 km) beyond the city limits.

[2] OR 422S begins at the intersection of Chocktoot Street and Chiloquin Road in Chiloquin and heads southeast, ending just past the Williamson River.