While the highway is signed east-to-west, it is in reality shaped somewhat like a horseshoe; heading north-northeast from Medford, turning east as it approaches the park, and then turning south-southeast as it approaches Klamath Falls.

About 6 miles (10 km) north of Medford, the highway passes through White City, where it intersects with OR 140.

Just short of the park, in the community of Union Creek, the highway intersects with Oregon Route 230, which provides a north–south bypass of Crater Lake.

A section of Route 62 between Medford and White City was moved to a new, four-lane freeway in May 2019.

The 4.5-mile (7.2 km) Rogue Valley Expressway cost $120 million and began construction in May 2016.