Hospital de Chinos became inadequate for the swelling number of Chinese residents in Manila, Philippines.

A fund raising campaign was done to construct the first Chinese General Hospital (CGH) with updated facilities in 1917.

In 1945, more than five hundred victims of shrapnel and bullets were admitted to the Chinese General Hospital, even occupying all available spaces in the corridors.

The hospital also catered training and teaching, as approved by Pedro Mayuga, former Director of the Philippine Bureau of Medical Services of the Department of Health.

Lim Ka-sian was appointed new director and James G. Dy as president of the Philippine Chinese Charitable Association in 1990s.

In 1996, the Heart Institute was built with renowned cardiologist Dy Bun Yok as Director and Manual Chua-Chiaco Jr. as the Chief in Cardiovascular Surgery.

In 2014, the hospital renewed a Memorandum of Agreement (MOA) with the Intelligence Service Armed Forces of the Philippines (ISAFP) assuring its personnel of free medical care at the CGHMC in the event they get injured while performing their duty.