It begins at an interchange with SR 167 in Sumner and travels southeast across the Cascade Range to a junction with U.S. Route 12 (US 12) in Naches.

The route starts as a limited-access southerly bypass of Downtown Sumner, but becomes a surface road east of the city.

Traveling eastward, the roadway serves Bonney Lake and Buckley, and crosses and eventually parallels the White River into Enumclaw and Greenwater.

Modern SR 410 was parts of various state wagon roads until 1926 when US 410 was established, extending from Aberdeen to Lewiston, Idaho.

[4] The highway travels southeast across suburban areas, crossing the Stuck River and passing a partial cloverleaf interchange with Linden Drive,[5] also named Traffic Avenue.

After a second partial cloverleaf interchange with Thompson Avenue, SR 410 goes under a railroad trestle owned by BNSF Railway and used by Amtrak's Cascades rail service,[6][7] near the northern bank of the Puyallup River.

SR 162 travels north into Downtown Sumner as Valley Avenue and south over the Puyallup River towards Orting.

[9] Continuing northeast, SR 410 connects to 166th Avenue and turns southeast as an undivided highway into the community of Bonney Lake.

In Buckley, the street travels northeast through Downtown and turns north to cross the White River and enter King County.

[1][11] The bridge ends in the community of Greenwater, named for the river, where the roadway encounters Forest Road 70, which has been proposed to become SR 168 over Naches Pass as an alternative to the Chinook Scenic Byway.

SR 410 is closed at the gate to Morse Creek, about 5 miles east of the Chinook Pass Summit during the winter and early spring due to high wind, limited cell service and avalanche danger.

On June 20, 1967, US 12 was extended west from Lewiston, Idaho, over White Pass to Aberdeen, eliminating most of the original route of the highway.

[43] On October 11, 2009, a massive landslide buried about 0.5 miles (0.80 km) of SR 410 west of Naches in the Nile Valley.

[46] A detour was set up on Nile Road and initially limited to use by local residents until opening up to all traffic on October 20.

[44][49][50] After three years, SR 410 was re-routed back to the east side of the Naches River along the toe of the landslide with a permanent route that opened in August 2012.