The airport is mainly used for general aviation and business travel; the Eau Claire-based Menards corporation uses CVRA to base their fleet of aircraft to serve their stores throughout the Midwest.

It is occasionally used as an alternative landing site for flights bound for Minneapolis-Saint Paul International Airport.

In 1929, Eau Claire Airways was started at the airport, offering training and scheduled taxi service to destinations in Wisconsin and Minnesota.

Sun Country's bid would have continued service to four nonstop destinations from Eau Claire in contrast to SkyWest's one city, Chicago.

SkyWest previously served the airport as an Essential Air Service provider until November 2022, before choosing to leave the market.

The Essential Air Service bid was approved by the Department of Transportation, SkyWest resumed with flights to O'Hare International Airport on December 13, 2024.

Chippewa Valley Regional Airport covers an area of 1,100 acres (450 ha) at an elevation of 913 feet (278 m) above mean sea level.

[1] For the 12-month period ending December 31, 2022, the airport had 18,897 aircraft operations, an average of 52 per day: 88% general aviation, 10% air taxi, 2% military and less than 1% scheduled commercial.