She has become popular due to "Takal So Yin" song from the group album "Yuu Aung Chit Mi Thu".

[13] In 2010, she released her debut solo album "Tain Twe Nay Tae Ayet" (Where The Cloud Lies) which spawned more huge hits.

[13] In 2007, she took on her first big-screen leading role in the film Nge Thu Moh Ma Thi Bar (Don't Know Because I Am Young) alongside Lu Min which screened in Myanmar cinemas in 2008.

[13] In 2011, she starred in her second big-screen film A Htar Thi Nae Nhint Khar Chit where she played the leading role with Nay Toe, Min Maw Kun, and Wutt Hmone Shwe Yi which screened in Myanmar cinemas in 2012.

[21] Chit Thu Wai has initiated a hygiene awareness program, promoting disease prevention through hand-washing with soap.

In 2015, she attended to the United Nations General Assembly as a Hand-washing Ambassador from Myanmar to raise awareness of handwashing with soap to help reduce child and newborn mortality.

At these events, she did galvanise support for the inclusion of handwashing as a hygiene indicator in the Sustainable Development Goals (SDGs) and spread the message about the importance of hand washing.

Among the events at the UNGA week, the highlight of Chit Thu Wai's role is her attendance and speech at the Unilever Hygiene and Nutrition Luncheon on 27 September.

The International Red Cross and UN organizations including the World Food Program and UNICEF were also on hand, independent of Chit Thu Wai, to offer humanitarian assistance.

Following the 2021 Myanmar coup d'état, Chit Thu Wai was active in the anti-coup movement both in person at rallies and through social media.

[27][28] On 6 April 2021, warrants for her arrest were issued under section 505 (a) of the Myanmar Penal Code by the State Administration Council for speaking out against the military coup.

Along with several other celebrities, she was charged with calling for participation in the Civil Disobedience Movement (CDM) and damaging the state's ability to govern, with supporting the Committee Representing Pyidaungsu Hluttaw, and with generally inciting the people to disturb the peace and stability of the nation.