[citation needed] She made her debut at the Royal National Theatre in a 2010 production of Men Should Weep alongside numerous other Scottish actors.

[citation needed] In 2013, she played a politician in "The Waldo Moment", an episode of the anthology series Black Mirror.

[1] In 2014, Pirrie starred in the BBC miniseries The Game, a Cold War spy thriller in which she played an MI5 secretary.

[3] She also starred in the Death In Paradise episode "In the Footsteps of a Killer" as Grace Matlock, an employee at the Saint Marie Times.

[6] In 2020, she appeared in Autumn de Wilde's film adaptation of Jane Austen's novel Emma as Isabella Knightley, elder sister of the titular character played by Anya Taylor-Joy.