She worked at the Samsung Advanced Institute of Technology as a senior researcher from 1999 until 2008[5] where she participated in developing in vitro diagnostic devices with biomedical applications.

From 2016, she is a full professor in the Department of Biomedical Engineering in UNIST[7][1] She has been an associate editor of Lab on a Chip from 2019[8] and previously served as an editorial board member (2013-2019).

[13] Cho and her team have developed lab-on-a-disc systems to provide a “sample-in and answer-out” type biochemical analysis solution with simple, size-reduced, and cost-efficient instrumentation.

[14] She demonstrated fully integrated virus enrichment and nucleic acids extraction on a chip,[15] fully automated immunoassay,[16][17][18] label-free isolation of circulating tumor cells,[19][20] size fractionization of extracellular vesicles (EVs),[21][22] RNA detection from urinary EVs,[23] and electricity-free bacteria enrichment for urinary tract infection detection and rapid antimicrobial susceptibility test[24] by directly testing clinical samples of patients, which allows high precision detection of biomarkers for monitoring the efficacy of therapy and emergent drug resistance for personalized medicine.

[28] In addition, her group is interested in nanomaterials, nanodevices, and nanofluidics which can provide nonconventional tools and platforms to enhance biosensing characteristics or to investigate physical, chemical, and biological properties of living matter.