C. bibronii has been used as an animal model in bioastronautic research examining the effects of spaceflight on the morphology and physiology of vertebrates.

[5] Bibron's gecko is distributed across the southern part of the African continent in Namibia, South Africa, and Eswatini.

[3] A moderate-sized gecko, C. bibronii reaches a total length (including tail) of 6 to 8 in (15 to 20 cm).

Its base color is brown, and it has a beaded pattern dorsally, with black crossbars.

[citation needed] Bibron's thick-toed gecko is arboreal and ground-dwelling.