The mature protein promotes chondrocyte growth and inhibits angiogenesis.

It may also be involved in the broad control of tissue vascularization during development.

Alternative splicing results in multiple transcript variants encoding different isoforms.

[7] Chondromodulin-I, an antiangiogenic factor isolated from cartilage, is abundantly expressed in cardiac valves.

Gene targeting of chondromodulin-I resulted in enhanced VEGF-A expression, angiogenesis, lipid deposition and calcification in the cardiac valves of aged mice.