The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia.

[5] CHRDL1 plays important roles in processes such as embryonic cell differentiation, osteogenesis, neurogenesis, tumor and metastasis suppression, and retinal formation.

[7][8] The highest expression of this gene is found in the anterior eye segment and retina as well as in the cerebellum and neocortex.

Since the gene limits synaptic plasticity, a mutation may cause issues in proper synapse maturation, leading to a variety of neurological disorders.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.