Chris Byrd vs. Wladimir Klitschko II, billed as "Revenge Is The Name Of The Game", was a professional boxing match contested on 22 April 2006 for the IBF and vacant IBO heavyweight championship.

[3] Klitschko had won four fights in his comeback from his shock defeat to Lamon Brewster while trying to regain the WBO title he had lost to Corrie Sanders in 2003.

Byrd had originally planned to fight then reigning WBA champion Nicolai Valuev;[5] he would instead go on to lose to Alexander Povetkin before briefly returning to the light heavyweight division and ultimately retiring in 2010 with the record of 41–5–1.

[6] Klitschko held the IBF title for a record-breaking 3,507 days before his defeat at the hands of Tyson Fury in November 2015.

This fight would mark the fourth time trainer Emanuel Steward guided a fighter to a Heavyweight title, after Evander Holyfield, Oliver McCall and Lennox Lewis.