Primarily known for his portraits of musicians, Cuffaro has photographed Michael Hutchence, Henry Rollins, George Michael, George Harrison and Jane's Addiction, among others.

He was closely associated with the Seattle rock scene of the early 1990s, and frequently photographed artists including Nirvana and Pearl Jam.

Most notably, he directed the first video for the Pearl Jam song "Jeremy."

Although Pearl Jam's label supported the effort - Cuffaro and Eddie Vedder had become friends—the label ultimately shelved the black-and-white video, instead commissioning a more commercial video when "Jeremy" was released as a single in 1991.

[3] Composed of 100 photographs, the first exhibition of Cuffaro's photography was held in Los Angeles in 1992 at Ministry.