In February 2011, his Eisner Award-nominated series, Zombies vs. Robots, co-created with artist Ashley Wood, was optioned by Sony Pictures for Michael Bay’s Platinum Dunes with Mike Flanagan as director.

Ryall, along with Web designer Ming Chen, news writer/editor Scott Tipton and many freelance columnists and cartoonists, launched the site on June 17, 2002.

[4] Ryall's first published comic-book work as writer with IDW was an adaptation of the film Shaun of the Dead with artist Zach Howard; he also helped launch the horror mag revival Doomed (for which he and artist Ashley Wood received an Eisner nomination for their adaptation of Richard Matheson's "Blood Son" short story), dialoguing the lead character, Ms.

In 2014, Ryall and Sam Kieth again partnered to launch a four-issue miniseries Mars Attacks: First Born.

[5] Among the properties he helped develop and shepherd to IDW Publishing were Hasbro's Transformers, Locke & Key, Toho’s Godzilla, CBS/Paramount's Star Trek, HBO's True Blood and 2000 AD's Judge Dredd.

He also published a short comic-book story with artist Drew Moss, "High Ball on the Low Road," in the Image Comics anthology "Outlaw Western, Vol.

Ryall wrote the first inter-company crossover for IDW in 2011: Infestation, which paired the Transformers, Star Trek, Ghostbusters, and G.I.

[10] In 2020, Ryall announced that he was stepping down from his duties with IDW in order to work with Ashley Wood again in a new publishing venture called the World of Syzygy, though he would continue as editor of the Locke & Key comic books, and executive producer of the television series.