At the age of 3 he moved with his family to New Delhi, India where he first discovered comics as he was unable to play outside due to the dangerous number of snakes in the house yard.

[2] Sprouse launched his career in mainstream comics in 1989, his first credited work being a Chemical King story in Secret Origins vol.

He then worked for Extreme Studios as the regular penciller of New Men, and in 1997–1998, Sprouse drew several issues of Supreme, scripted by Alan Moore for the same publisher.

After Supreme ended, he and Moore created Tom Strong for America's Best Comics,[6] for which Sprouse won two Eisner Awards in 2000, for Best Single Issue and Best Serialized Story.

[12] Other works include Batman '66, Fairest: In All the Land, The Flash, Sensation Comics Featuring Wonder Woman, Agents of S.H.I.E.L.D., and Thors.