Chris Wolstenholme grew up in the English town of Rotherham before moving to Teignmouth, Devon, where he played drums for a post-punk band.

Bellamy and Howard convinced Wolstenholme to take up bass and start a new band with them, initially called Rocket Baby Dolls.

[1] The members of Muse played in separate school bands during their stay at Teignmouth Community College in the early 1990s.

They asked Wolstenholme, at that time the drummer for the band Fixed Penalty, to join as the bassist; he agreed and took up bass lessons.

[4] Rather than simply playing root notes, Wolstenholme's basslines often perform a lead role, such as in the 2003 song "Hysteria".

"[7] Wolstenholme wrote and sang lead vocals on two Muse songs, "Liquid State" and "Save Me", from their sixth album, The 2nd Law (2012).

[10][11] In August 2024, Wolstenholme announced a solo project, Chromes, and released the singles "Imaginary World" and "The Good Life".

[24] His bandmates did not notice his problem for several years; according to Bellamy, "He's such a good musician that his motor skills or something just aren't affected.