Weisse was born in Leipzig, and studied at the university there, at first adhering to the Hegelian school of philosophy.
[4] He developed (along with I. H. Fichte with whom he regularly corresponded after 1829)[5] a new speculative theism, and became an opponent of Hegel's idealism.
In his work on philosophical dogmatics (Philosophische Dogmatik oder Philosophie des Christentums, 3 vols., 1855–1862) he seeks, by idealizing all the Christian dogmas, to reduce them to natural postulates of reason or conscience.
[6] Weisse was the first theologian to propose the two-source hypothesis (1838), which is still held by a majority of biblical scholars today.
[citation needed] Weisse was a contributor to I. H. Fichte's academic journal Zeitschrift für Philosophie und spekulative Theologie.