He played college football for the Missouri Tigers and Oklahoma State Cowboys and was selected by the Washington Commanders in the seventh round of the 2022 NFL draft.

Holmes played cornerback and wide receiver for McNair High School in Atlanta, Georgia.

As a true freshman for the Missouri Tigers, he played minimally in 10 games and recorded only a single tackle.

[1] He played in 13 games as a redshirt sophomore and started eight, recording 12 pass break-ups and two interceptions, one of which he returned for a touchdown.

[8] In Week 6 against the Chicago Bears, Holmes made a key special teams play in the fourth quarter when he recovered a muffed punt by Chicago returner Velus Jones Jr. on the Bears six-yard line.