He played college football for the Alabama Crimson Tide and was selected by the Washington Commanders in the second round of the 2022 NFL draft.

[3] Mathis was rated a four-star recruit and committed to play college football at Alabama over offers from LSU and TCU.

He played in all 15 of the Crimson Tide's games as a redshirt freshman and was named to the Southeastern Conference (SEC) All-Freshman team.

[12] In his NFL debut, Mathis tore the meniscus in his left knee and was placed on injured reserve.

[17] Mathis made 12 appearances for Washington in 2024, recording one pass deflection and 17 tackles, prior to being waived on December 28, 2024.