Christiane Sophie Charlotte of Brandenburg-Kulmbach (15 October 1733 in Neustadt an der Aisch – 8 October 1757 in Jagdschloss Seidingstadt in Straufhain) was a member of the Kulmbach-Bayreuth branch of the Franconian line of the House of Hohenzollern and was, by marriage, Duchess of Saxe-Hildburghausen.

Christiane Sophie Charlotte was the only surviving child of Margrave Frederick Christian of Brandenburg-Bayreuth from his marriage to Victoria Charlotte, the daughter of Prince Victor Amadeus Adolf I of Anhalt-Bernburg-Schaumburg-Hoym.

After mediation by her aunt, Christiane married on 20 January 1757 at Christiansborg Palace to the Queen's former son-in-law Duke Ernest Frederick III of Saxe-Hildburghausen.

Christiane was describe as very pious; however, and unlike her predecessor (who had insisted on rigid court etiquette), she had a lavish lifestyle, with elaborate parties and had a special fondness for hunting.

At the entrance of the former Jagdschloss Seidinstadt, two antlers are on display, from two deer she shot while hunting in 1757.