The eastern Emperor John VIII Palaeologus, pressed hard by the Ottoman Turks, was keen to ally himself with the West, and to do so he arranged with Pope Eugene IV for discussions about reunion to be held again, this time at the Council of Ferrara-Florence.
After several long discussions, the emperor managed to convince the Eastern representatives to accept the Western doctrines of Filioque, Purgatory and the supremacy of the Papacy.
On 6 June 1439, an agreement was signed by all the Eastern bishops present but one, Mark of Ephesus, who held that Rome continued in both heresy and schism.
However, upon their return, the Eastern bishops found their agreement with the West broadly rejected by the populace and by civil authorities (with the notable exception of the emperors of the East who remained committed to union until the Fall of Constantinople two decades later).
Eastern Christians expressed a belief that the fall of Constantinople was God's punishment for the emperor and clergy accepting the West's doctrines of filioque, purgatory and the supremacy of the papacy.
As a result of the Ottoman conquest of the Byzantine Empire in 1453, and the Fall of Constantinople, the entire Orthodox communion of the Balkans and the Near East became suddenly isolated from the West.
The patriarch, as the highest ranking hierarch, was thus invested with civil and religious authority and made ethnarch, head of the entire Christian Orthodox population.
The legal privileges of the patriarch and the Church depended, in fact, on the whim and mercy of the Sultan and the Sublime Porte, while all Christians were viewed as second-class citizens.
Devshirmeh was the system of the collection of young boys from conquered Christian lands by the Ottoman sultans as a form of regular taxation in order to build a loyal army (formerly largely composed of war captives) and the class of (military) administrators called the "Janissaries", or other servants such as tellak in hamams.
The remainder of the Church of Antioch, primarily local Greeks or Hellenized sections of the indigenous population, remained in communion with Rome, Constantinople, Alexandria, and Jerusalem.
Since sources are silent, historians concluded that the period of vacancy was prolonged, resulting in de facto abolition of the Patriarchal office.
The Italian Renaissance was a period of great cultural change and achievement, marked in Italy by a classical orientation and an increase of wealth through mercantile trade.
On the other hand, wealthy Italian families often secured episcopal offices, including the papacy, for their own members, some of whom were known for immorality, such as Alexander VI and Sixtus IV.
The 14th century was also a time in which movements of widely varying character worked for the reform of the institutional church, such as conciliarism, Lollardy and the Hussites.
These frustrated reformist movements ranged from nominalism, devotio moderna (modern devotion), to humanism occurring in conjunction with economic, political and demographic forces that contributed to a growing disaffection with the wealth and power of the elite clergy, sensitizing the population to the financial and moral corruption of the secular Renaissance church.
In the emerging urban centers, however, the calamities of the 14th and early 15th century, and the resultant labor shortages, provided a strong impetus for economic diversification and technological innovations.
Following the Black Death, the initial loss of life from famine, plague, and pestilence contributed to an intensification of capital accumulation in the urban areas and thus a stimulus to trade, industry, and burgeoning urban growth in fields as diverse as banking (the Fugger banking family in Augsburg and the Medici family of Florence being the most prominent); textiles, armaments, especially stimulated by the Hundred Years' War, and mining of iron ore with the booming armaments industry.
As a direct result of the move toward centralization, leaders like Louis XI of France sought to remove all constitutional restrictions on the exercise of their authority.
But as recovery and prosperity progressed, enabling the population to reach its former levels in the late 15th and 16th centuries, the combination of both a newly abundant labor supply as well as improved productivity, were 'mixed blessings' for many segments of Western European society.
Ongoing, earnest theoretical debates occurred in the universities about the nature of the church, and the source and extent of the authority of the papacy, of councils, and of princes.
Pope Alexander VI, in the papal bull Inter caetera, awarded colonial rights over most of the newly discovered lands to Spain and Portugal.
[8] On December 1511, the Dominican friar Antonio de Montesinos openly rebuked the Spanish authorities governing Hispaniola for their mistreatment of the American natives, telling them "... you are in mortal sin ... for the cruelty and tyranny you use in dealing with these innocent people".