She married on 3 October 1722 in Braunfels to Landgrave Casimir William of Hesse-Homburg (1690-1726).

The princess took care of the education of her children; for this purpose she appointed the theologian August Friedrich Sack as court tutor.

In 1727, he published his Conseils d'un ami à jeune homme qui entre dans le monde, describing the education of her son.

Casimir William died at the age of 36, shortly after the birth of their third child.

In 1727, the Reichskammergericht in Wetzlar confirmed the appointment of Christine Charlotte as regent for her underage son.