She has released eight albums:[1] six in the Spanish-language and one in the English-language, Christine D'Clario (2005), Solo tú... lo único que quiero (2008), De Vuelta al Jardín (2011), Más Profundo and Deeper (2013), Eterno Live (2015), and Emanuel (2018).

The album was produced by Chris Rocha and it includes the songs "Padre Nuestro", "Crea en mí" and "Encenderé esta ciudad".

[6] De Vuelta al Jardín includes D'Clario's signature song "Como Dijiste", as well as the hit singles "Gloria en lo alto" and "Él nos ama".

In 2014, her collaboration with Dominican rapper Redimi2, "El Nombre de Jesús" gained international success for both artists, reaching more than 150 millions of views on YouTube.

Later, in 2015, D'Clario and Guatemalan band Miel San Marcos released the successful hit "No hay lugar más alto".

[11] Following the release of Eterno Live, D'Clario appeared on several songs: "Tu eres Rey" with Barak, "Dios de lo Imposible" with Marco Barrientos and David Reyes, "Por la Eternidad" with Redimi2 and Julio Melgar, "Mi Libertador" with Miel San Marcos and "Lugar Secreto" with Gabriela Rocha.

On January 10, 2020, she appeared in duet with Tauren Wells in his single "Tu poder (Yo creo en ti)" which is the Spanish version of his song "Famous For (I believe)".