Since 2001, Talbot has been the main co-anchor of Calendar, appearing with Geoff Druett until Friday 23 May 2003 and is now currently alongside Duncan Wood.
On 30 June 2021 Christine presented her final Calendar after 20 years at ITV Yorkshire.
On 30 January 2012, it was announced on Calendar that Talbot had been diagnosed with breast cancer, and would be taking a break from the programme for treatment and recovery.
On 29 June 2012, Talbot spoke to local newspaper Yorkshire Evening Post about her illness.
[4] On 28 December 2012 it was revealed Talbot had "undergone a gruelling 12 months" and would return to work on 14 January 2013.