Froschauer was born in Neuburg near Oettingen (Bavaria) and acquired Zürich citizenship on 9 November 1519, as a gift "for his art."
He learned the printer's trade with his uncle, Hans Froschauer, in Augsburg and came to Zurich in 1515.
A dispute over the sausage eating organized by Froschauer in his workshop during Lent in 1522 brought about open conflict between Zwingli and the clerical establishment, thus setting off the Reformation in Zürich.
The historical workshop was at the northern boundary of the Froschau, at Brunngass 18, facing the Zähringerplatz.
He printed the works of Erasmus von Rotterdam, Luther and notably of Zwingli.