Christopher Columbus Upson (October 17, 1829 – February 8, 1902) was a U.S. Representative from Texas.

Born near Syracuse, New York, Upson attended the common schools and Williams College, Williamstown, Massachusetts.

During the Civil War he served in the Confederate States Army as a volunteer aide, with the rank of colonel, on the staff of Gen. W.H.C.

Upson was elected as a Democrat to the Forty-sixth Congress to fill the vacancy caused by the death of Gustave Schleicher.

He resumed the practice of law in San Antonio, Texas, and died there February 8, 1902.