Morel signed with the Cubs as an international free agent in 2015, and made his MLB debut with them in 2022.

Morel made his major league debut later that day, and hit a home run in his first career at-bat during a 7–0 win over the Pittsburgh Pirates.

[7] Upon his promotion, Morel became the first Cub in franchise history to record nine home runs in his first 12 games of a season on May 23, 2023.

[9] Morel made 103 appearances for Chicago in 2024, hitting .199/.302/.373 with 18 home runs, 57 RBI, and 7 stolen bases.

[10] On July 28, 2024, the Cubs traded Morel, Hunter Bigge, and Ty Johnson to the Tampa Bay Rays in exchange for Isaac Paredes.