Shyer has appeared in multiple guest roles on television since 1994, including: Viper, The New Outer Limits, Smallville, Monk, JAG, CSI: Miami, CSI: Crime Scene Investigation, and a critically acclaimed recurring role as the Hannibal Lecter-like character "Lawrence O'Malley" in The Practice.
He more recently appeared in a supporting role on ABC-TV's re-imagined V series as "Marcus," second-in-command to the V high commander, Anna (Morena Baccarin).
His varied film roles have included The Falling (1998, as "Lars"), The Invitation (2003, as "Joel Gellman"), The Lazarus Child (2004, as "John Boyd"), Fierce People (2005, as "Dr. Leffler"), and Big Bad Wolf (2006, as "Charlie Cowley").
He has also starred on Broadway as Sam Carmichael in Mamma Mia and Dean Newhouse in Going Down Swingin’, following successful stints in the Canadian productions of Miss Saigon, Les Misérables (as Joly & understudy Marius Pontmercy), The Phantom of the Opera (as Raoul, Vicomte de Chagny), Assassins (as John Wilkes Booth), and Sunset Boulevard (as Artie Green).
He also played four supporting roles in the US tour of The Book of Mormon and Governor John Slaton in 2025 US tour of Parade.