He pursued graduate coursework at the University of Illinois at Chicago receiving a Master of Fine Arts in painting in 1991.
Sperandio is an assistant professor at Rice University in the School of Visual and Dramatic Arts.
Grennan and Sperandio were commissioned to make new work for the international contemporary art survey Traffic, curated by Nicolas Bourriaud, and their works have often been exhibited with other "Relational Art" practitioners, such as Rirkrit Tiravanija and Maurizio Cattelan.
Typical of these is the "Invisible City" project for the Public Art Fund and "Modern Masters" produced for PS1/MoMA.
Kartoon Kings: The Graphic Work of Simon Grennan and Christopher Sperandio, a monograph collecting images and information on their collaborative practice was published in 2007.