[2] As a resident of lower Manhattan in the late 1970s, Rupp exhibited in early artist-run spaces including Exit Art, 3 Mercer Street Store (a precursor to Fashion Moda,[3] Franklin Furnace, the Kitchen, Artists Space, The Clocktower and PS1 International Studio Program, and ABC No Rio.
Her work appeared in early publications of The Soho News, East Village Eye, Heresies: A Feminist Publication on Art and Politics,[8][9][10] World War 3 Illustrated[11] The first publicly visible work was "The Rat Patrol," which was an outdoor poster project of a life-size rat pasted where garbage accumulated, pointing out the fact the city is a living ecosystem with a delicate balance.
Art critic Douglas Crimp reflected on this work by writing, "Surely a photograph of a rat borrowed from Health Department files and mechanically reproduced is not a creation of artistic imagination; it has no claim to universality; it would be unthinkable to see the picture on exhibition in a museum.
One example being the Watershed Glassware, a set of glasses for drinking tap water, featuring printed images of "perfectly harmless" organisms like Giardia, Cryptosporidium, and Fluoride.
Recent works include sculptures of fake ivory and its association with commercial arms trade and oil extraction.