Chronic allograft nephropathy (CAN) is a kidney disorder which is the leading cause of kidney transplant failure,[1] occurring months to years after the transplant.

CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.

[2] The histopathology is characterized by interstitial fibrosis, tubular atrophy, fibrotic intimal thickening of arteries and glomerulosclerosis.

[2][3] CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.

[4]