Chronotherapy, also called chronotherapeutics[1] or chronotherapeutic drug delivery,[2] refers to the coordination of therapeutic treatments with an individual's circadian or other rhythmic cycles.
This may be done to maximize effectiveness of a specific treatment, minimize possible side effects, or both.
[3][4] In the treatment of psychiatric conditions including bipolar depression,[5][6] a form of chronotherapy combining intermittent sleep deprivation and morning bright light has shown efficacy and relative tolerability in a number of controlled studies.
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