In development from February 1996 to December 1999, the Generation IV minivans were based on the Chrysler RS platform and featured a larger body frame with modified headlights and taillights.

Unveiled at the 2000 North American International Auto Show (NAIAS) on Monday, January 10, 2000,[2] the RS minivans were released for sale in August 2000.

Trim levels for the Caravan and Town & Country were carried over from the previous generation, while the Voyager was only offered in a base model.

In addition to other detailed changes, remote operated sliding doors and rear hatch, which could be opened and closed at the push of a button, either inside the vehicle, or with the keyless entry fob, became options, as well as a new tri-zone climate control system and side seat mounted airbags.

This year also saw the appearance of an optional factory-installed rear seat DVD system with single disc player mounted below the HVAC controls, and the addition of a SXT model.

This package was offered on higher level SXT models, and included chrome wheels, body color moldings, special interior accents and a unique fender badge.

Taiwanese-market Town & Country minivans were assembled between 2005 and 2007 in Yangmei, Taiwan under license by the China Motor Corporation, starting with the 2006 model year.

Taiwanese models featured minor variations for the local market including LED taillights, backup cameras and mirror-mounted turn signals.

In 2004, Chrysler introduced a system of second- and third-row seating that folded completely into under-floor compartments, marketed as Stow 'N Go and available exclusively on long-wheelbase models.

In a development program costing $400 million,[8] engineers initially used an Erector Set to visualize the complex interaction of the design[9] and redesigned under-floor components.

[8][10] The Stow 'n Go system received the Popular Science Magazine's "Best of What's New" for 2005 award,[11] and was never offered on the Volkswagen Routan, the rebadged nameplate variant of the Chrysler minivans.

For the subsequent minivan generation, beginning in model year 2011, Chrysler revised the system, rebranding it as "Super Stow 'n Go".

The 4th generation Town & Country (Grand Voyager, as it is known in Europe))right hand drive (RHD) version performed very poorly in the Euro NCAP car safety tests and achieved the following ratings:[12]