Chrystian Gabriel Colombo (born 1952) is an Argentine businessman and politician who served as Chief of the Cabinet of Ministers during the presidency of Fernando de la Rúa, from 2000 to 2001.

Later, Colombo worked in the private sector as part of Gupo Pérez Companc, as a stockbroker in the Buenos Aires Stock Exchange, as vice president of the Sociedad de la Bolsa Macro, and as manager of the Banco Río de la Plata (later Banco Santander Río) stock market.

Just a year later, on 6 October 2000, De la Rúa appointed Colombo as Chief of the Cabinet of Ministers, in replacement of Rodolfo Terragno.

Under Colombo's leadership, Ricardo López Murphy was designated at the helm of the Ministry of Economy following the resignation of José Luis Machinea.

In 2001, he was denounced by the Anti-Corruption Bureau for mishandling of public funds during his time as president of the Banco Nación;[3] further charges were presented before the National Senate in 2002.