Charles Albert Comiskey II (November 19, 1925 – August 26, 2007) was part-owner of the Chicago White Sox from 1956 to 1961.

During his time in the White Sox front office, Comiskey played an important role in developing the minor league system of the Go-Go Sox teams of the late 1950s, ultimately culminating with the team's winning the American League championship in 1959.

[citation needed] In 1956, Comiskey became co-general manager along with his brother-in-law Johnny Rigney, replacing Frank Lane.

Seeing a chance to finally gain control of the team, Comiskey sold his stock to a group headed by Chicago insurance magnate William Bartholomay.

Comiskey promised Bartholomay that he would be able to overwhelm the Allyns with an offer for total control, allowing him an opportunity to buy the team.