[10] Hoskin ran unopposed for his Tribal Council seat in the 2013 Cherokee elections, which due to redistricting was now district 11, being sworn in on August 14, 2013.

[11][12] In August 2013, Hoskin was nominated and confirmed to be the Cherokee Nation's Secretary of State by Principal Chief Bill John Baker.

He resigned his Cherokee Tribal Council seat and was sworn in on August 21, 2013, triggering a special election that was won by Victoria Vazquez.

[14] Hoskin resigned as Secretary of State on February 6, 2019, to file run for Principal Chief of the Cherokee Nation.

[16] Before taking his oath of office, he announced his intent to invest $30 million into repairing homes for Cherokees who have previously been on a waiting list under the tribe's housing rehabilitation program.

[21] Hoskin and Warner also proposed the creation of the Cherokee Nation's first Secretary of Veterans Affairs, which, upon approval, will be a cabinet-level position.

Hoskin has nominated former Deputy Principal Chief Joe Crittenden, a Vietnam-era Navy veteran, to hold this position.

[22] He ran for re-election in the 2023 Cherokee Nation principal chief election and received over 50% of the vote on the first round, avoiding a runoff.

[25] Hoskin has criticized Governor Kevin Stitt for pushing back against the McGirt decision, saying that "the governor 'is trying to convince the public that there is chaos because of McGirt where there is not chaos"[26] and that Stitt "has been bent on destroying the tribes.”[27] In July 2022, Hoskin issued an executive order that no Oklahoma state flag should be flown on Cherokee property,[28] but later restored the flags due to backlash.