He played seven seasons for the Cleveland Browns (1955–1956), the Chicago Cardinals (1956–1958), and the Philadelphia Eagles (1959–1961).
He played college football for the West Chester Golden Rams.
After retirement, he worked as defensive coordinator for Cincinnati Bengals and Baltimore Colts, where he succeeded teammate Maxie Baughan.
Weber grew up in suburban Philadelphia and went to Abington High School.
Weber resided in San Diego, California and died on October 22, 2017, at the age of eighty-seven.