The school was operated by the Christ Church before its 1971 nationalisation.

Azizullah Sharif of Dawn stated that CMS, while operated by the church, was "one of the best educational institutions of the city where many students passed their matric examinations with flying colours.

"[1] As of 2010, four institutions occupy the complex: CMS Primary School, CMS Secondary School, Cutchhi Memon Association (CMA) Primary, and CMA Girls Secondary School.

[1] In 2010, Pir Mazhar-ul-Haq, the Minister of Education of Sindh, ordered restoration of the three original blocks of the school, unused, after seeing them in a poor physical condition.

Shabbir Jokhio, the district officer of male secondary schools and high schools, did not appear for the visit, so Mazhar-ul-Haq suspended him from his job.