In 1861, Monsignor Steins, Vicar Apostolic of Bombay passing through Belgium, called Mother Marie Therese, Superior General and founder of the Daughters of the Cross, and asked for several of her sisters to work in the Indian mission field.

The school was founded in 1862 by the planning of Monsignor Steins, Vicar Apostolic of Bombay of that time and five Sisters of the Cross.

Thus, on 13 March 1862, five Daughters of the Cross first set foot on the sandy soil of Sindh, and immediately began their apostolate to the people of Karachi.

In 1869 an upper storey was added to the Convent, providing accommodation for the boarders and from January 1871 the institution was known as St Joseph's Covent.

In 1958 the swimming pool was closed and transformed into the Lourdes House, and in 1965 a part of the garden saw the raising of the present Primary Block.

The people who migrated to Pakistan were looking for schools for their children and the Sisters responded generously, stretching their capacity to the limit.