In 1554, the city began the construction of another church to replace the original one, but did not complete it.
In 1560, the Jesuits took possession of the site and completed it by 1597, calling it the church of the Annunciation of the Blessed Mary.
The 18th century Blessed Antonio Baldinucci developed a particular devotion to the Refugium Peccatorum (Refuge of Sinners) image of Virgin Mary in the church, which has been considered miraculous.
The Jesuits spread copies of the image to Mexico by the 19th century and it began to be depicted in missions there.
This article about a Roman Catholic church building in Italy is a stub.