Santissimo Crocifisso ("Holy Crucifix", also dedicated to San Francesco da Paola) is a Catholic church in Alcamo, in the province of Trapani, Sicily, southern Italy.

It was founded in 1550 in the name of the Most Holy Crucifix by the nobleman Pietro Tabone, grandfather of the poet Sebastiano Bagolino’s, who was buried in this Church.

[1] In 1542 Tabone, after his request, had a piece of land by the municipality in order to build a Chapel dedicated to the Most Holy Crucifix, patron saint of the town at that time.

[2] In 1575 there was a terrible plague: the population in Alcamo, about 7,700, was cut in half, according to the historian Ignazio De Blasi and a lot of people were buried in the cemetery Sant'Ippolito, in the western suburb.

Inside it there the following works: On the high altar: the Crucifix, a wooden sculpture made by Francesco Marino from Trapani in the 19th century.